Divarasib (GDC-6036)

Name: Divarasib (GDC-6036)
Brand: Adooq Bioscience
SKU: A24528
Rating: 5 (288 reviews)

Catalog No.: A24528

KRAS G12C inhibitor

Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS^G12C inhibitor with an IC₅₀ of <0.01 μM. It covalently binds to the switch II (SW-II) pocket of KRAS^G12C, irreversibly locking the protein in its inactive GDP-bound conformation.

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Divarasib (GDC-6036) 2417987-45-0 KRAS G12C inhibitor

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Grouped product items
Size	Price	Stock
1mg	$225.00	In stock
5mg	$675.00	In stock
10mg	$1,150.00	In stock
50mg	$3,450.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Biological Activity

Description	Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS^G12C inhibitor with an IC₅₀ of <0.01 μM. It covalently binds to the switch II (SW-II) pocket of KRAS^G12C, irreversibly locking the protein in its inactive GDP-bound conformation.

Product Information

Catalog Num	A24528
Formula	C29H32ClF4N7O2
Molecular Weight	622.06
CAS Number	2417987-45-0
SMILES	NC1=N[C@]([C@]2=C(C=C3C(N=C(N=C3N4[C@H](CN(CC4)C(C=C)=O)C)OC[C@H]5N(CCC5)C)=C2F)Cl)=C(C(C)=C1)C(F)(F)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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