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DM-4107

MRP4 Inhibitor

DM-4107 is a potent inhibitor of the MRP4 transporter, demonstrating inhibitory capabilities on human liver transporters including NTCP, BSEP, MRP3, and MRP4, with IC50 values of 95.6, 119, 61.2, and 37.9 μM, respectively. This compound is primarily a metabolite of Tolvaptan and is metabolized by the CYP3A4 enzyme in the liver. DM-4107 is particularly relevant for research into autosomal dominant polycystic kidney disease (ADPKD) as it impacts bile acid transport in primary human hepatocyte (SCHH) cells.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1346599-75-4
Applications	MRP4 Inhibitor
Formula	C₂₆H₂₅ClN₂O₅
Molecular Weight	480.94
SMILES	CC1=CC=CC=C1C(NC2=CC(C)=C(C(NC3=C(C(O)CCC(O)=O)C=C(Cl)C=C3)=O)C=C2)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.