Fig. 1 · Structure
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DM-PIT-1
PIP3/PH Interaction Inhibitor
DM-PIT-1 is a potent inhibitor of the PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction. It effectively reduces the phosphorylation levels of key survival proteins, including Akt, GSK-3β, p70S6K, S6, and 4E-BP1, thereby promoting apoptosis. This compound demonstrates significant anticancer activity, making it a valuable tool for research in ovarian cancer and other malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 701947-53-7 |
| Applications | PIP3/PH Interaction Inhibitor |
| Formula | C16H15N3O4S |
| Molecular Weight | 345.37 |
| Synonyms | 3,5-Dimethyl PIT-1 |
| SMILES | O=C(C1=CC(C)=CC(C)=C1)NC(NC2=C(C=CC([N+]([O-])=O)=C2)O)=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.