dMCL1-2

Catalog No.: A18378

MCL-1/PROTAC degrader

dMCL1-2

dMCL1-2 Chemical Structure

CAS NO. 2351218-88-5

dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.6 mL 42.98 mL 85.96 mL
0.5 mM 1.72 mL 8.6 mL 17.19 mL
1 mM 0.86 mL 4.3 mL 8.6 mL
5 mM 0.17 mL 0.86 mL 1.72 mL

*The above data is based on the productmolecular weight 1163.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18378
Actions Degrader
CAS No. 2351218-88-5
Formula C61H66N10O12S
M. Wt 1163.3
Purity >98%
SMILES O=S(N(CC1)CCN1C(C=C2)=CC=C2OCC3=C(C4=C(N(CCN5CCN(C(COC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)CC5)C(C(O)=O)=C9CCCOC%10=C(C=CC=C%11)C%11=CC=C%10)C9=CC=C4)C(C)=NN3C)(N(C)C)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy dMCL1-2 | dMCL1-2 Supplier | purchase | cost | manufacturer | order | distributor | buy 2351218-88-5| 2351218-88-5 Supplier | purchase 2351218-88-5 | 2351218-88-5 cost | 2351218-88-5 manufacturer | order 2351218-88-5 | 2351218-88-5 distributor
Rewards