DMOG

Catalog No.: A13998

HIF-PH inhibitor

DMOG

DMOG Chemical Structure

CAS NO. 89464-63-1

DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.

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100 mg
$110.00
200 mg
$190.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hideaki Nakamura, .et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 PMID: 29466367

Biological Activity

DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.
Targets
HIF prolyl hydroxylase
In vitro DMSO 33 mg/mL (188.42 mM)
Water 33 mg/mL (188.42 mM)
Ethanol 33 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 57.1 mL 285.49 mL 570.97 mL
0.5 mM 11.42 mL 57.1 mL 114.19 mL
1 mM 5.71 mL 28.55 mL 57.1 mL
5 mM 1.14 mL 5.71 mL 11.42 mL

*The above data is based on the productmolecular weight 175.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13998
Actions Inhibitor
CAS No. 89464-63-1
Formula C6H9NO5
M. Wt 175.14
Purity >98%
Synonyms Dimethyloxaloyl glycine
SMILES COC(=O)CNC(=O)C(=O)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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