Fig. 1 · Structure
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DMP 811
AT1 Antagonist
DMP 811 is a highly selective angiotensin II subtype receptor AT1 antagonist, with an IC50 of 6 nM for AT1 and an IC50 of >10 μM for AT2, demonstrating its specificity. This compound exhibits significant antihypertensive effects in animal models, including rats and dogs. DMP 811 is suitable for investigations into hypertension mechanisms and associated therapeutic approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 139964-19-5 |
| Applications | AT1 Antagonist |
| Formula | C23H24N6O2 |
| Molecular Weight | 416.49 |
| SMILES | O=C(O)C1=C(N=C(N1CC=2C=CC(=CC2)C=3C=CC=CC3C4=NN=NN4)CCC)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.