DMP 904

Catalog No.: A58072
CRFR Antagonist
DMP 904 is a noncompetitive antagonist of the corticotropin-releasing factor receptor (CRFR), effectively inhibiting CRF-stimulated adenylate cyclase activity and adrenocorticotropic hormone (ACTH) release. This compound demonstrates significant antidepressant and anxiolytic properties, making it a valuable tool for research in stress-related disorders and neuropsychiatric conditions. Its mechanism of action can provide insights into the therapeutic potential for anxiety and depression treatments.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDMP 904 is a noncompetitive antagonist of the corticotropin-releasing factor receptor (CRFR), effectively inhibiting CRF-stimulated adenylate cyclase activity and adrenocorticotropic hormone (ACTH) release. This compound demonstrates significant antidepressant and anxiolytic properties, making it a valuable tool for research in stress-related disorders and neuropsychiatric conditions. Its mechanism of action can provide insights into the therapeutic potential for anxiety and depression treatments.
Product Information
Catalog NumA58072
FormulaC21H28N4O
Molecular Weight352.47
CAS Number202579-74-6
SMILESCC1=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN2C(NC(CC)CC)=C1
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