Fig. 1 · Structure
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DMT-2'O-Methyl-rU Phosphoramidite
DNA/RNA Synthesi
DMT-2'O-Methyl-rU Phosphoramidite is a 2'-O-methylated derivative utilized in the synthesis of oligonucleotides. Its primary mechanism involves the incorporation of 2'-O-methyluridine into RNA sequences, enhancing stability and reducing susceptibility to nucleases. This reagent is essential for applications in RNA synthesis, therapeutic development, and in the creation of modified nucleic acids for research studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 110764-79-9 |
| Applications | DNA/RNA Synthesi |
| Formula | C40H49N4O9P |
| Molecular Weight | 760.81 |
| Synonyms | 2'-O-Me-U Phosphoramidite |
| SMILES | COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@H](N5C(NC(C=C5)=O)=O)O4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.