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DMU371

KRS1 Inhibitor

DMU371 is a selective inhibitor of lysyl-tRNA synthetase 1 (KRS1) in Trypanosoma cruzi, exhibiting an IC50 of 185 nM. This compound demonstrates significant potential for studying the mechanisms of infectious diseases, particularly in the context of Chagas disease. Its role in inhibiting KRS1 contributes to the exploration of new therapeutic strategies against this parasitic infection.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3052352-34-5
Applications	KRS1 Inhibitor
Formula	C₁₄H₁₅F₃N₄
Molecular Weight	296.29
SMILES	NC1=C2C(F)=C(F)C(NC3CCCC3)=C(F)C2=NC(C)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.