Fig. 1 · Structure
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DN-1289
DLK/LZK Inhibitor
DN-1289 is a selective inhibitor targeting dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK), exhibiting IC50 values of 17 nM and 40 nM, respectively. This compound demonstrates substantial attenuation of p-c-Jun expression in a mouse model following optic nerve crush injury. DN-1289 is characterized by a favorable in vivo plasma half-life and effective blood-brain barrier permeability, making it a valuable tool for research into neurodegeneration and related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3026597-15-6 |
| Applications | DLK/LZK Inhibitor |
| Formula | C18H19F4N7O2 |
| Molecular Weight | 441.38 |
| SMILES | NC1=C(OC(F)F)N=C(C2=NC(N3[C@@H](C4)CO[C@@H]4C3)=NC(N5CCC(F)(F)C5)=C2)C=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.