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DNA Repair

DNA repair inhibitors and activators act on enzymes that detect and fix damaged bases and broken strands. A 1993 review estimated that hydrolysis and oxidation damage thousands of DNA bases in every cell each day. In base excision repair, 8-oxoguanine DNA glycosylase 1 (OGG1) excises oxidized guanine, and apurinic/apyrimidinic endonuclease 1 (APE1) then cuts the abasic site. TH10785 is listed as an OGG1 activator, whereas APE1-IN-1 inhibits APE1. DNA repair protein RAD52 homolog (RAD52) became a target after a 2011 study found its loss lethal in cells lacking breast cancer susceptibility protein 2 (BRCA2). D-I03 inhibits RAD52, HAMNO blocks replication protein A (RPA), and CD00509 inhibits tyrosyl-DNA phosphodiesterase 1 (TDP1).

Cat. No.

A37702

CAS No.

3032393-24-8

UNC9512

UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which plays a crucial role in the DNA damage response. This compound can be utilized to investigate the functions of 53BP1 in various biological processes, including DNA repair mechanisms, gene editing efficiencies, and tumorigenesis. Its application supports research aimed at understanding the underlying molecular pathways related to genomic stability and cancer development.

In stock View Details

1 mg

$360.00

5 mg

$920.00

All 3 sizes

DNA Repair

UNC9512