Fig. 1 · Structure
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DNDI-6174
Cytochrome bc1 Complex Inhibitor
DNDI-6174 is a potent inhibitor of the cytochrome bc1 complex, demonstrating significant in vitro activity against multiple Leishmania species. This compound effectively reduces parasite burden in animal models of infection, making it valuable for research into potential therapeutic strategies for leishmaniasis. Its selective mechanism offers insights into the metabolic pathways of these pathogens, contributing to the development of targeted treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2868298-43-3 |
| Applications | Cytochrome bc1 Complex Inhibitor |
| Formula | C16H13N5O2 |
| Molecular Weight | 307.31 |
| SMILES | N#CC1=CC=C(C2=C(C)NC3=NC(N)=NC(C)=C32)C4=C1OCO4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.