Fig. 1 · Structure
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DNL343
ISR Inhibitor
DNL343 is a selective, orally active inhibitor of eukaryotic initiation factor eIF2B, specifically targeting the integrated stress response (ISR) in the central nervous system (CNS). This compound demonstrates significant potential in reversing neurodegeneration and neuroinflammation, as well as preventing motor dysfunction and premature mortality in eIF2B loss-of-function mutant mice. DNL343 serves as an important tool for investigating the mechanisms underlying neurodegenerative diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2278265-85-1 |
| Applications | ISR Inhibitor |
| Formula | C20H19ClF3N3O4 |
| Molecular Weight | 457.83 |
| SMILES | ClC(C=C1)=CC=C1OCC(NC23CC(C3)(C4=NN=C([C@@H]5C[C@@H](C5)OC(F)(F)F)O4)C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.