Fig. 1 · Structure
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Docetaxel-d9
Stable Isotope
Docetaxel-d9 is a deuterium-labeled derivative of Docetaxel, a potent microtubule-depolymerization inhibitor with an IC50 of 0.2 μM. It modulates the expression of apoptosis-regulating genes such as bcl-2 and bcl-xL, leading to cell cycle arrest at the G2/M phase and subsequent cell apoptosis. This compound is utilized in cancer research to investigate its mechanistic pathways and therapeutic potential in various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 940867-25-4 |
| Applications | Stable Isotope |
| Formula | C43H44D9NO14 |
| Molecular Weight | 816.93 |
| Synonyms | RP-56976-d9 |
| SMILES | CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)O)=C([C@H](C4)OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)C)C)O)OC(C6=CC=CC=C6)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.