Domperidone

Catalog No.: A10329

Domperidone

Domperidone Chemical Structure

CAS NO. 57808-66-9

Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).

Availability: In stock

Package Price Qty
100 mg
$55.00
500 mg
$160.00
10mM * 1mL in DMSO
$50.00
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Biological Activity

Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).
Targets
Dopamine D2 receptor
In vitro DMSO 48 mg/mL (112.69 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.34 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.48 mL 117.4 mL 234.79 mL
0.5 mM 4.7 mL 23.48 mL 46.96 mL
1 mM 2.35 mL 11.74 mL 23.48 mL
5 mM 0.47 mL 2.35 mL 4.7 mL

*The above data is based on the productmolecular weight 425.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10329
M. Wt 425.91
Formula C22H24ClN5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 57808-66-9
SMILES C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

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