Donitriptan hydrochloride

Catalog No.: A29560
5-HT1B/1D Receptor Agonist
Donitriptan hydrochloride is a potent agonist of the 5-HT1B and 5-HT1D receptors, exhibiting high efficacy with pKis of 9.4 and 9.3, respectively. This compound is primarily utilized in research focused on migraine treatments and the modulation of serotonin pathways. Its strong receptor activity makes it a valuable tool for studying the pharmacological effects of serotonin receptor signaling in various biological contexts.
Grouped product items
Size Price Stock Qty
2mg
$30.00
In stock
5mg
$35.00
In stock
10mg
$50.00
In stock
25mg
$115.00
In stock
50mg
$205.00
In stock
100mg
$285.00
In stock
200mg
$360.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDonitriptan hydrochloride is a potent agonist of the 5-HT1B and 5-HT1D receptors, exhibiting high efficacy with pKis of 9.4 and 9.3, respectively. This compound is primarily utilized in research focused on migraine treatments and the modulation of serotonin pathways. Its strong receptor activity makes it a valuable tool for studying the pharmacological effects of serotonin receptor signaling in various biological contexts.
Product Information
Catalog NumA29560
FormulaC23H26ClN5O2
Molecular Weight439.94
CAS Number170911-68-9
SMILESN#CC1=CC=C(N2CCN(C(COC3=CC4=C(NC=C4CCN)C=C3)=O)CC2)C=C1.[H]Cl
SynonymsF-11356
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