Fig. 1 · Structure
Documents & Downloads
Dornase alfa
rhDNase
Dornase alfa is a recombinant human deoxyribonuclease I (rhDNase) that specifically degrades extracellular DNA. By catalyzing the cleavage of DNA released by neutrophils in respiratory mucus, Dornase alfa reduces sputum viscosity, enhancing mucus clearance and alleviating airway obstruction. This compound is primarily utilized in the treatment of cystic fibrosis, where it improves lung function and decreases the risk of acute pulmonary exacerbations through localized aerosol inhalation. Its efficacy in ameliorating respiratory symptoms associated with DNA accumulation makes it an important reagent for research applications in respiratory health.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 143831-71-4 |
| Applications | rhDNase |
| Synonyms | rhDNase |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.