Fig. 1 · Structure
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DOTAP methylsulfate
Cationic Lipid
DOTAP methylsulfate is a cationic lipid that facilitates the delivery of nucleic acids into cells. This reagent self-assembles with negatively charged molecules, such as DNA, and enhances cellular uptake through mechanisms of electrostatic interaction and endocytosis. Additionally, DOTAP methylsulfate promotes endosomal membrane fusion, allowing for the efficient release of DNA into the cytoplasm. Its applications are significant in gene therapy, cell transfection, and the development of non-viral vectors for gene delivery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 144189-73-1 |
| Applications | Cationic Lipid |
| Formula | C43H83NO8S |
| Molecular Weight | 774.19 |
| Synonyms | 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate |
| SMILES | S(OC)(=O)(=O)[O-].C(OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.