Fig. 1 · Structure
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Dothiepin
antidepressant agent
Dothiepin is an antidepressant agent primarily acting as a norepinephrine reuptake inhibitor while exerting substantial sedative and anxiolytic effects. Its mechanism enhances noradrenergic neurotransmission by inhibiting neuronal uptake of norepinephrine. Additionally, Dothiepin serves as a histamine H1 receptor antagonist, demonstrating a favorable cardiotoxicity profile. This compound also exhibits significant analgesic activity in conditions such as psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis, making it valuable for diverse therapeutic research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 113-53-1 |
| Applications | antidepressant agent |
| Formula | C19H21NS |
| Molecular Weight | 295.44 |
| Synonyms | Dosulepin; Dothep |
| SMILES | CN(C)CC/C=C1C2=CC=CC=C2SCC3=CC=CC=C/13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.