Fig. 1 · Structure
Documents & Downloads
Dovitinib-d8
Stable Isotope
Dovitinib-d8 is a deuterated form of Dovitinib, a multi-targeted tyrosine kinase inhibitor. Dovitinib exhibits potent inhibitory activity against various kinases, including FLT3, c-Kit, FGFR1, VEGFR1, and PDGFR, with IC50 values ranging from 1 to 210 nM. This stable isotope-labeled reagent is particularly valuable in pharmacokinetic studies, enabling researchers to investigate drug metabolism and distribution in biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1246819-84-0 |
| Applications | Stable Isotope |
| Formula | C21H13D8FN6O |
| Molecular Weight | 400.48 |
| SMILES | NC1=C(C2=NC3=CC=C(N4C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C4([2H])[2H])C)C=C3N2)C(NC5=CC=CC(F)=C51)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.