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|Storage||at -20°C 3 years Powder|
|Synonyms||CHIR-258, CHIR258, TKI258|
|Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.|
|Solubility (25°C) *||In vitro||DMSO||30 mg/mL (76.44 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||30% PEG400/0.5% Tween80/5% propylene glycol||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||25.48 mL||127.42 mL||254.84mL|
|0.5 mM||5.1 mL||25.48 mL||50.97 mL|
|1 mM||2.55 mL||12.74 mL||25.48 mL|
|5 mM||0.51 mL||2.55 mL||5.1 mL|
*The above data is based on the productmolecular weight 392.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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