Fig. 1 · Structure
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DQP-997-74
NR2C/D Inhibitor
DQP-997-74 is a selective negative allosteric modulator of the N-methyl-D-aspartate receptor (NMDAR), specifically targeting the GluN2C and GluN2D subunits with IC50 values of 0.069 μM and 0.035 μM, respectively. This compound exhibits blood-brain barrier penetrability and demonstrates synergistic effects with glutamate, resulting in enhanced inhibition of hypersynchronous neural activity under high-frequency excitatory synaptic transmission. DQP-997-74 has shown potential to reduce epileptogenesis in murine models of tuberous sclerosis complex (TSC)-induced epilepsy, making it a valuable tool for research on NMDAR-related neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2377187-09-0 |
| Applications | NR2C/D Inhibitor |
| Formula | C28H19Cl2F2N3O4 |
| Molecular Weight | 570.37 |
| SMILES | O=C(CC(F)(C(N1N=C(CC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=C(Cl)C=C4)C5=C(C=CC=C5)NC3=O)=O)F)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.