Fig. 1 · Structure
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Dropropizine ((±)-Dropropizine, UCB-196)
Antitussive Agent
Dropropizine is a peripherally selective antitussive agent that primarily acts by inhibiting the activity of peripheral receptors and afferent nerves in the respiratory tract. It effectively regulates sensory neuropeptide levels and interrupts the cough reflex pathway without crossing the blood-brain barrier, thereby minimizing central nervous system side effects. With additional mild local anesthetic and antihistamine properties, dropropizine is primarily utilized in research focused on symptomatic relief of dry cough associated with various respiratory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 17692-31-8 |
| Applications | Antitussive Agent |
| Formula | C13H20N2O2 |
| Molecular Weight | 236.31 |
| Synonyms | (±)-Dropropizine; UCB-196 |
| SMILES | OCC(O)CN1CCN(C2=CC=CC=C2)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.