Fig. 1 · Structure
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Drupanin
AKR1C3 Inhibitor
Drupanin is a selective inhibitor of the AKR1C3 enzyme and an RXRα agonist, exhibiting an EC50 of 4.8 μM. This compound also demonstrates moderate activation of PPARγ, contributing to its role in inducing adipogenesis and elevating aP2 mRNA levels in 3T3-L1 fibroblasts. Drupanin holds promise for studies investigating breast and prostate cancer biology and therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 53755-58-1 |
| Applications | AKR1C3 Inhibitor |
| Formula | C14H16O3 |
| Molecular Weight | 232.28 |
| SMILES | C/C(C)=C\CC1=C(C=CC(/C=C/C(O)=O)=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.