Documents & Downloads

DS01080522

PRKACA Inhibitor

DS01080522 is a selective inhibitor of Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA). It effectively inhibits PRKACA kinase activity with an IC50 of 0.8 nM and reduces CREB phosphorylation with an IC50 of 66 nM. This compound is valuable for researching the role of PRKACA in various cancer models and exploring potential therapeutic strategies.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2832159-84-7
Applications	PRKACA Inhibitor
Formula	C₂₃H₂₀Cl₂N₄O₃
Molecular Weight	471.34
SMILES	O=C(N[C@H]([C@@]1([H])C[C@H](O)CN1)C2=CC(Cl)=C(C#N)C=C2)C3=CC4=CC=NC(Cl)=C4C=C3OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.