Fig. 1 · Structure
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DS69910557
hPTHR1 Antagonist
DS69910557 is a potent and selective antagonist of the human parathyroid hormone receptor 1 (hPTHR1), exhibiting an IC50 value of 0.08 μM. This compound is useful for investigating the biological mechanisms underlying conditions such as hyperparathyroidism, hypercalcemia of malignancy, and osteoporosis. Its oral bioactivity makes DS69910557 a valuable tool for preclinical studies focused on modulating hPTHR1 signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 3032750-17-4 |
| Applications | hPTHR1 Antagonist |
| Formula | C32H33Cl2FN4O3 |
| Molecular Weight | 611.53 |
| SMILES | ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.