Fig. 1 · Structure
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DS89002333
PRKACA Inhibitor
DS89002333 is a potent inhibitor of PRKACA, exhibiting an IC50 of 0.3 nM. This compound demonstrates significant anti-tumor activity in a patient-derived xenograft model of fibrolamellar hepatocellular carcinoma (FL-HCC) characterized by the presence of the DNAJB1-PRKACA fusion gene. DS89002333 serves as a valuable tool for research on FL-HCC and its underlying molecular mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2832159-79-0 |
| Applications | PRKACA Inhibitor |
| Formula | C22H20ClF2N3O3 |
| Molecular Weight | 447.86 |
| SMILES | O=C(N[C@H]([C@]1([H])C[C@@H](O)CN1)C2=CC(Cl)=C(F)C=C2)C3=CC4=CC=NC(F)=C4C=C3OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.