Fig. 1 · Structure
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DSRM-3716
SARM1 Inhibitor
DSRM-3716 is a selective inhibitor of SARM1 (Sterile Alpha and TIR Motif-Containing 1) with a potent inhibitory capacity, showcasing an IC50 of 75 nM. It specifically targets the NADase activity of SARM1 while demonstrating selectivity against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 is particularly useful in research applications focused on neuroprotection, as it offers significant axonal protection in cellular models of neurodegeneration.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 58142-99-7 |
| Applications | SARM1 Inhibitor |
| Formula | C9H6IN |
| Molecular Weight | 255.06 |
| Synonyms | 5-Iodoisoquinoline |
| SMILES | IC1=CC=CC2=C1C=CN=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.