Fig. 1 · Structure
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DTME
Maleimide Crosslinker
DTME (dithio-bis-maleimidoethane) is a homobifunctional maleimide crosslinker that targets sulfhydryl groups (-SH) for specific conjugation. Its unique molecular structure consists of two maleimide groups linked by an ethylene disulfide bridge, enabling stable covalent bonding with thiol-containing molecules, including cysteine residues. DTME is particularly useful for studying protein structure and dynamics, facilitating investigations into oligomerization and protein-protein interactions. Additionally, the crosslinks formed with DTME can be cleaved using reducing agents such as DTT, providing versatility in experimental applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 71865-37-7 |
| Applications | Maleimide Crosslinker |
| Formula | C12H12N2O4S2 |
| Molecular Weight | 312.36 |
| Synonyms | Dithio-bis-maleimidoethane |
| SMILES | O=C(C=C1)N(CCSSCCN2C(C=CC2=O)=O)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.