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DTS-108

SN38 Prodrug

DTS-108 is a prodrug of SN38, functioning as a Topoisomerase I inhibitor. By conjugating SN38 to a human oligopeptide through an esterase-sensitive cross-linker, DTS-108 enhances targeted delivery and potency. This compound demonstrates significant anti-tumor activity in colorectal, lung, and mammary cancers, making it a valuable tool for cancer research and therapeutic investigations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	951792-83-9
Applications	SN38 Prodrug
Formula	C₁₄₅H₂₃₃N₄₃O₃₃S₂
Molecular Weight	3170.80
SMILES	C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)[C@@H]6CC[C@@H](CNC(=O)[C@@H]7CC[C@@H](CN8C(=O)C(SC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC9=CN=CN9)C(N[C@H](C(N[C@H](C(=O)N%10[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)CC(O)=O)=O)CCSC)=O)CCCNC(=N)N)=O)[C@@H](C)O)=O)C(C)C)=O)CCCNC(=N)N)=O)CCC%10)CCCNC(=N)N)=O)C(C)C)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)[C@H](C)C)=O)N)CC8=O)CC7)CC6)=CC5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.