Fig. 1 · Structure
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Duvelisib (R enantiomer)
PI3K Inhibitor
Duvelisib (R enantiomer) is a selective inhibitor of phosphoinositide 3-kinase (PI3K), targeting the delta and gamma isoforms. It exhibits antitumor activity by inhibiting cell proliferation and promoting apoptosis in various cancer models. This compound is primarily utilized in research focused on cancer treatment, immune response modulation, and signaling pathway analysis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1261590-48-0 |
| Applications | PI3K Inhibitor |
| Formula | C22H17ClN6O |
| Molecular Weight | 416.86 |
| Synonyms | IPI-145 R enantiomer; INK1197 R enantiomer |
| SMILES | ClC1=C(C2=O)C(C=C([C@H](NC3=NC=NC4=C3N=CN4)C)N2C5=CC=CC=C5)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.