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DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.51 mL | 97.53 mL | 195.07 mL |
| 0.5 mM | 3.9 mL | 19.51 mL | 39.01 mL |
| 1 mM | 1.95 mL | 9.75 mL | 19.51 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.9 mL |
*The above data is based on the productmolecular weight 512.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18491 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2243709-60-4 |
| Formula | C31H36N4O3 |
| M. Wt | 512.64 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | DW 14800, DW-14800 |
| SMILES | CN(C)C1=CC=C(C(N2CCC(C=C(C(NCC(O)CN3CC(C=CC=C4)=C4CC3)=O)C=C5)=C5C2)=O)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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