DW14800

Catalog No.: A18491

PRMT5 inhibitor

DW14800

DW14800 Chemical Structure

CAS NO. 2243709-60-4

DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.51 mL 97.53 mL 195.07 mL
0.5 mM 3.9 mL 19.51 mL 39.01 mL
1 mM 1.95 mL 9.75 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.9 mL

*The above data is based on the productmolecular weight 512.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18491
Actions Inhibitor
CAS No. 2243709-60-4
Formula C31H36N4O3
M. Wt 512.64
Solubility DMSO
Purity >98%
Synonyms DW 14800, DW-14800
SMILES CN(C)C1=CC=C(C(N2CCC(C=C(C(NCC(O)CN3CC(C=CC=C4)=C4CC3)=O)C=C5)=C5C2)=O)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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