Dyclonine hydrochloride is a potent inhibitor of aldehyde dehydrogenases (ALDH), specifically targeting ALDH2 with an IC50 of 35 μM and ALDH3A1 with an IC50 of 76 μM. This compound exhibits notable biological activities, including the sensitization of targeted cancer cells and antibacterial properties. Additionally, Dyclonine hydrochloride serves as a local anesthetic, effectively inhibiting nerve impulse transmission and alleviating pain sensations. Its ability to cross the blood-brain barrier further enhances its utility in various research applications.
Dyclonine hydrochloride is a potent inhibitor of aldehyde dehydrogenases (ALDH), specifically targeting ALDH2 with an IC50 of 35 μM and ALDH3A1 with an IC50 of 76 μM. This compound exhibits notable biological activities, including the sensitization of targeted cancer cells and antibacterial properties. Additionally, Dyclonine hydrochloride serves as a local anesthetic, effectively inhibiting nerve impulse transmission and alleviating pain sensations. Its ability to cross the blood-brain barrier further enhances its utility in various research applications.
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