Dyrk1A-IN-15 is a selective, ATP-competitive inhibitor of DYRK1A with an IC50 of 19 nM. This compound demonstrates high selectivity for DYRK kinases and nanomolar potency across various kinase assays. In vitro studies reveal that Dyrk1A-IN-15 disrupts neurosphere self-renewal, inhibits cell invasion, and destabilizes EGFR. Additionally, it shows the ability to inhibit tumor growth and extend survival in vivo, indicating its potential utility in glioblastoma research.
Dyrk1A-IN-15 is a selective, ATP-competitive inhibitor of DYRK1A with an IC50 of 19 nM. This compound demonstrates high selectivity for DYRK kinases and nanomolar potency across various kinase assays. In vitro studies reveal that Dyrk1A-IN-15 disrupts neurosphere self-renewal, inhibits cell invasion, and destabilizes EGFR. Additionally, it shows the ability to inhibit tumor growth and extend survival in vivo, indicating its potential utility in glioblastoma research.
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