Dyrk1A-IN-4 is a selective DYRK1A and DYRK2 inhibitor, known for its potent activity with IC50 values of 2 nM and 6 nM, respectively. This compound effectively inhibits DYRK1A autophosphorylation at pSer520 in U2OS cells, displaying an IC50 of 28 nM. Dyrk1A-IN-4 is useful for investigating the roles of DYRK1A in various cancer types, including ovarian adenocarcinoma, neuroblastoma, and cervical squamous cell carcinoma.
Dyrk1A-IN-4 is a selective DYRK1A and DYRK2 inhibitor, known for its potent activity with IC50 values of 2 nM and 6 nM, respectively. This compound effectively inhibits DYRK1A autophosphorylation at pSer520 in U2OS cells, displaying an IC50 of 28 nM. Dyrk1A-IN-4 is useful for investigating the roles of DYRK1A in various cancer types, including ovarian adenocarcinoma, neuroblastoma, and cervical squamous cell carcinoma.
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