Dyrk1A-IN-5 is a potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It demonstrates notable selectivity for DYRK1B and CLK1, with IC50 values of 600 nM and 500 nM, respectively, while showing minimal activity against DYRK2 (IC50 > 10 μM). This compound is particularly valuable for research related to Down syndrome, facilitating the exploration of DYRK1A's role in cellular mechanisms associated with this condition.
Dyrk1A-IN-5 is a potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It demonstrates notable selectivity for DYRK1B and CLK1, with IC50 values of 600 nM and 500 nM, respectively, while showing minimal activity against DYRK2 (IC50 > 10 μM). This compound is particularly valuable for research related to Down syndrome, facilitating the exploration of DYRK1A's role in cellular mechanisms associated with this condition.
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