DYRK2-IN-2 is a selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2), exhibiting an IC50 of 40.3 nM. This compound demonstrates low inhibitory activity against other DYRK family members and CDC-like kinases, making it a specific tool for studying DYRK2. DYRK2-IN-2 effectively inhibits tau protein phosphorylation at Thr212 and exhibits moderate cytotoxicity in HT22 neuronal cells. This reagent is valuable for investigating the role of DYRK2 in cancer biology and neurodegenerative diseases.
DYRK2-IN-2 is a selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2), exhibiting an IC50 of 40.3 nM. This compound demonstrates low inhibitory activity against other DYRK family members and CDC-like kinases, making it a specific tool for studying DYRK2. DYRK2-IN-2 effectively inhibits tau protein phosphorylation at Thr212 and exhibits moderate cytotoxicity in HT22 neuronal cells. This reagent is valuable for investigating the role of DYRK2 in cancer biology and neurodegenerative diseases.
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