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(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium trifluoromethanesulfonate

LptA/LptC Ligand

(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium trifluoromethanesulfonate is a potent Ligand for LptA/LptC, functioning as a Gram-negative outer membrane permeabilizer. This compound exhibits synergistic antibacterial activity by inhibiting the interaction of LptA and LptC, specifically targeting Met47 in LptA. It enhances the efficacy of pol B against both wild-type and multidrug-resistant strains of Acinetobacter baumannii and Escherichia coli, making it a valuable tool for research into antibiotic adjuvants against multidrug-resistant Gram-negative bacteria.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2811663-45-1
Applications	LptA/LptC Ligand
Formula	C₂₆H₃₆F₃NO₄S
Molecular Weight	515.63
SMILES	O=S(C(F)(F)F)([O-])=O.CCN(CC)C(C=C1)=CC=C1/C=C/C2=CC(C(C)(C)C)=[O+]C(C(C)(C)C)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.