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E-2508 free base

CRF1 Antagonist

E-2508 free base is a highly selective antagonist of the corticotropin-releasing factor type 1 (CRF1) receptor, exhibiting potent anxiolytic effects with a Ki value of 11 nM. By inhibiting CRF1, E-2508 free base effectively blocks CRF-induced cAMP accumulation, thereby modulating stress response pathways. This compound is valuable for research into stress-related psychiatric disorders, including anxiety and depression, facilitating the study of potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	685885-75-0
Applications	CRF1 Antagonist
Formula	C₂₉H₃₉N₃O₄
Molecular Weight	493.64
SMILES	CCC1=NN2C(C3=C(C=C(C=C3OC)COC)OC)=CC=CC2=C1N(CC4CCOCC4)CC5CC5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.