Fig. 1 · Structure
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(E) -4-Hydroxycrotonic acid
Ligand For GHB
(E)-4-Hydroxycrotonic acid is a high-affinity ligand for gamma-hydroxybutyric acid (GHB) binding sites, exhibiting an inhibitory constant (Ki) value of 1.1 μM. The compound's structural modifications, including the incorporation of diaryl substituents, enhance its binding affinity, achieving Ki values between 0.023 and 0.075 μM. This reagent is valuable for studying GHB receptor interactions and aids in the design of optimized ligands and three-dimensional pharmacophore models for drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 24587-49-3 |
| Applications | Ligand For GHB |
| Formula | C4H6O3 |
| Molecular Weight | 102.09 |
| Synonyms | trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA |
| SMILES | O=C(O)/C=C/CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.