Fig. 1 · Structure
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(E)-Dothiepin hydrochloride
Antidepressant Agent
(E)-Dothiepin hydrochloride is an antidepressant agent primarily acting as a noradrenaline uptake inhibitor. By facilitating noradrenergic neurotransmission, it exerts both sedative and anxiolytic effects while also exhibiting antagonistic activity at the histamine H1 receptor, without cardiotoxicity. Additionally, (E)-Dothiepin hydrochloride demonstrates significant analgesic properties, making it useful in the research of conditions such as psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 25627-36-5 |
| Applications | Antidepressant Agent |
| Formula | C19H22ClNS |
| Molecular Weight | 331.90 |
| Synonyms | (E)-Dosulepin hydrochloride; (E)-Dothep hydrochloride |
| SMILES | CN(C)CC/C=C1C2=CC=CC=C2CSC3=CC=CC=C3\1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.