Fig. 1 · Structure
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(E)-Guanabenz
α2-adrenoceptor Agonist
(E)-Guanabenz is an orally active α2-adrenoceptor agonist that primarily functions by stimulating central α2-adrenoceptors, leading to a reduction in sympathetic outflow and antihypertensive effects. In addition to its cardiovascular benefits, (E)-Guanabenz directly inhibits GADD34, contributing to its neuroprotective properties. This compound is valuable for research focused on hypertension management and the investigation of Parkinson's disease mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 60329-03-5 |
| Applications | α2-adrenoceptor Agonist |
| Formula | C8H8Cl2N4 |
| Molecular Weight | 231.08 |
| Synonyms | (E)-Wy-8678 |
| SMILES | ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.