Fig. 1 · Structure
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(E/Z)-Droloxifene
ER Modulator
(E/Z)-Droloxifene is a selective estrogen receptor modulator (SERM) consisting of a mixture of (E)-droloxifene and (Z)-droloxifene. (E)-Droloxifene exhibits a potent binding affinity for the estrogen receptor, with an IC50 value of 24 nM in rabbit uterine homogenates, and is capable of increasing uterine weight in immature rats while inhibiting estradiol-induced effects in juvenile rats. Additionally, it effectively suppresses the growth of estrogen-dependent human breast cancer cell lines, including MCF-7, ZR-75-1, and T47D. In contrast, (Z)-droloxifene demonstrates weak binding to the estrogen receptor and lacks significant estrogenic or antiestrogenic activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 165813-01-4 |
| Applications | ER Modulator |
| Formula | C26H29NO2 |
| Molecular Weight | 387.51 |
| Synonyms | (E/Z)-3-Hydroxytamoxifen |
| SMILES | OC1=CC=CC(/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)/C3=CC=CC=C3)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.