Fig. 1 · Structure
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(E/Z)-IT-603
IĸBα/c-Rel Inhibitor
(E/Z)-IT-603 is an IĸBα/c-Rel inhibitor, consisting of a mixture of E-IT-603 and Z-IT-603. This compound exhibits anti-tumor activity with an IC50 of 3 μM against c-Rel. (E/Z)-IT-603 has shown potential as a modulator of T-cell responses, making it valuable for research applications in graft-versus-host disease (GVHD) and various malignant conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 292168-90-2 |
| Applications | IĸBα/c-Rel Inhibitor |
| Formula | C11H9BrN2O3S |
| Molecular Weight | 329.17 |
| SMILES | O=C(/C(N1)=C\C2=CC(Br)=CC(OC)=C2O)NC1=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.