Fig. 1 · Structure
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(E/Z)-NSAH
Ribonucleotide Reductase Inhibitor
(E/Z)-NSAH is a reversible, competitive inhibitor of ribonucleotide reductase (RR). This compound exhibits a cell-free IC50 of 32 μM and a cell-based IC50 of approximately 250 nM, making it a valuable tool for studying nucleotide metabolism and cellular proliferation. Its ability to inhibit RR positions it as a significant reagent for research in cancer biology and antiviral therapies, where modulation of nucleotide pools is critical.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 54009-54-0 |
| Applications | Ribonucleotide Reductase Inhibitor |
| Formula | C18H14N2O3 |
| Molecular Weight | 306.32 |
| SMILES | O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.