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E09241

Osteoclastogenesis Inhibitor

E09241 is an orally active osteoclastogenesis inhibitor that targets Wnt/β-catenin signaling. It effectively reduces RANKL-induced expression of NFATc1 and MMP-9, while also enhancing the OPG/RANKL ratio through the upregulation of OPG expression. E09241 inhibits bone resorption, promotes bone formation, and serves as a preventive agent against ovariectomy-related bone loss. This compound is valuable for research applications focused on osteoporosis and related bone disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1043110-13-9
Applications	Osteoclastogenesis Inhibitor
Formula	C₁₁H₉ClN₂O₂
Molecular Weight	236.66
SMILES	O=C(NC1=NC=CC(=C1)C)C=2OC(Cl)=CC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.