Fig. 1 · Structure
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E197
DOCK5 Inhibitor
E197 is a selective inhibitor of DOCK5, targeting the regulatory pathways of osteoclast function. It disrupts the podosome belt structure in osteoclasts, resulting in the inhibition of bone resorption with an IC50 of 3.44 μM in human osteoclasts. Additionally, E197 inhibits Rac activity in DOCK5-expressing HEK293 cells with an IC50 of 36 μM. This compound demonstrates potential in preventing bone loss, as evidenced in mouse ovariectomized models, making it a valuable tool for research in osteoporosis and bone pathology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2378515-04-7 |
| Applications | DOCK5 Inhibitor |
| Formula | C19H21ClN2O3S |
| Molecular Weight | 392.90 |
| SMILES | O=S1([C@]2(CN(CC2)CC3=CC=C(C=C3)Cl)[C@H](CN1C4=CC=CC=C4)O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.