Fig. 1 · Structure
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E235
ATF4 Regulator
E235 is a selective regulator of the transcription factor ATF4, known for its role in cellular stress responses. This compound induces cell viability reduction through the activation of the integrated stress response (ISR) and DNA damage response pathways. E235 exhibits anti-proliferative effects, making it a valuable tool for research in tumor biology and therapeutic development targeting stress-induced cellular mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 891894-69-2 |
| Applications | ATF4 Regulator |
| Formula | C28H25FN4OS |
| Molecular Weight | 484.59 |
| SMILES | O=C(C1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(F)C=C4)=C3)NC5CCN(CC6=CC=CC=C6)CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.