Fig. 1 · Structure
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E2508
CRF1 Receptor Antagonist
E2508 is an orally active antagonist of the corticotropin-releasing factor 1 (CRF1) receptor, exhibiting a Ki value of 11 nM for human CRF1. This compound plays a crucial role in research related to stress response and anxiety disorders by blocking CRF1-mediated signaling pathways. E2508 is useful for studies investigating therapeutic approaches for conditions associated with dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 685886-34-4 |
| Applications | CRF1 Receptor Antagonist |
| Formula | C36H47N3O7S |
| Molecular Weight | 665.84 |
| SMILES | CCC1=NN2C(C3=C(OC)C=C(COC)C=C3OC)=CC=CC2=C1N(CC4CC4)CC5CCOCC5.O=S(C6=CC=C(C)C=C6)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.