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E3 ligase Ligand 22

Cereblon Binder

E3 Ligase Ligand 22 is a cereblon binder that facilitates the targeted degradation of Ikaros and Aiolos proteins through the ubiquitin-proteasome pathway. This compound is valuable for studies investigating protein homeostasis, immune regulation, and the mechanism of action of immunomodulatory drugs. Its selective interaction with cereblon makes it a useful tool for researchers exploring targeted protein degradation strategies in various biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2377849-57-3
Applications	Cereblon Binder
Formula	C₂₈H₃₄N₆O₄
Molecular Weight	518.61
SMILES	CC1(CCC1)CN2CCC(CC2)N3C=C(C=N3)CNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.