E3 ligase Ligand 22

Catalog No.: A80596
Cereblon Binder
E3 Ligase Ligand 22 is a cereblon binder that facilitates the targeted degradation of Ikaros and Aiolos proteins through the ubiquitin-proteasome pathway. This compound is valuable for studies investigating protein homeostasis, immune regulation, and the mechanism of action of immunomodulatory drugs. Its selective interaction with cereblon makes it a useful tool for researchers exploring targeted protein degradation strategies in various biological contexts.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 Ligase Ligand 22 is a cereblon binder that facilitates the targeted degradation of Ikaros and Aiolos proteins through the ubiquitin-proteasome pathway. This compound is valuable for studies investigating protein homeostasis, immune regulation, and the mechanism of action of immunomodulatory drugs. Its selective interaction with cereblon makes it a useful tool for researchers exploring targeted protein degradation strategies in various biological contexts.
Product Information
Catalog NumA80596
FormulaC28H34N6O4
Molecular Weight518.61
CAS Number2377849-57-3
SMILESCC1(CCC1)CN2CCC(CC2)N3C=C(C=N3)CNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O
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